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Nature publishes a research article prepared by members of the epilepsy team

The title is “Seizure localization using pre ictal phase-amplitude coupling in intracranial electroencephalography” (SREP-19-30382), by Nuria E. Cámpora, Camilo J. Mininni, Silvia Kochen & Sergio E. Lew


Understanding changes in brain rhythms provides useful information to predict the onset of a seizure and to localize its onset zone in epileptic patients. Brain rhythms dynamics in general, and phaseamplitude coupling in particular, are known to be drastically altered during epileptic seizures. However, the neural processes that take place before a seizure are not well understood. We analysed the phaseamplitude coupling dynamics of stereoelectroencephalography recordings (30 seizures, 5 patients) before and after seizure onset. Electrodes near the seizure onset zone showed higher phase-amplitude coupling. Immediately before the beginning of the seizure, phase-amplitude coupling dropped to values similar to the observed in electrodes far from the seizure onset zone. Thus, our results bring accurate information to detect epileptic events during pre-ictal periods and to delimit the zone of seizure onset in patients undergoing epilepsy surgery.

The article “Seizure localization using pre ictal phase-amplitude coupling in intracranial electroencephalography” (SREP-19-30382), by Nuria E. Cámpora, Camilo J. Mininni, Silvia Kochen & Sergio E. Lew, was published on line by Scientific Reports on 27 December 2019 and can be read at www.nature.com/articles/s41598-019-56548-y.

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